The Latest News
- February 10, 2021 Definition of the NEDD8 Proteome in Homeostatic and Proteotoxic Stress conditions reveals a role for hybrid NEDD8-SUMO-2 chains in nuclear Protein Quality Control Scientists from Dimitris Xirodimas (CRBM, University of Montpellier) and Petra Belis Lab (Institute of Molecular Biology- IMB, Mainz) have discovered distinct proteomes for canonical and atypical NEDDylation by proteome-wide identification of NEDD8 modification sites. The study is published in Cell Reports.
- September 4, 2020 Autophagy: the beginning of the end Scientists led by Sascha Martens from the Max Perutz Labs, a joint venture of the University of Vienna and the Medical University of Vienna, have now reconstructed the first steps in the formation of autophagosomes. They show that tiny vesicles loaded with the protein Atg9 act as the seed from which the autophagosome emerges. The study is published in Science.
- August 31, 2020 An ancient bridge between autophagy and quality control at the endoplasmic reticulum New work published in eLife, from an international team led by the Dagdas lab at the Gregor Mendel Institute, has identified an evolutionary conserved protein that mediates recycling of the endoplasmic reticulum.
- August 4, 2020 Drug discovery: First rational strategy to find molecular degraders The group of Georg Winter at CeMM and his collaborators have described a strategy that, for the first time, enables the rational and highly scalable discovery of novel molecular glue degraders. Their findings have now been published in Nature Chemical Biology.
- July 8, 2020 Sascha Martens elected EMBO Member The EMBO (European Molecular Biology Organization) membership honours distinguished scientists who have made outstanding contributions in the life sciences. Sascha Martens is among this year's newly elected members.
- June 19, 2020 Tenure-Track Professorship in the field of Cellular Quality Control The Centre for Molecular Biology of the University of Vienna (Max Perutz Labs) is seeking an outstanding scientist to establish an internationally competitive research group in “Cellular Quality Control”. Research areas of particular interest include, but are not exclusive to, the quality control and repair of macromolecules, organelle homeostasis, ubiquitin signaling, autophagy, the targeted degradation of proteins and other macromolecules...
- June 10, 2020 Four outstanding scientists have joined our Scientific Advisory Board We are honored and proud to announce that four outstanding scientists - Judith Frydman (Stanford University), Ramanujan Hegde (MRC-LMB), Noboru Mizushima (University of Tokyo) and Hidde Ploegh (Harvard Medical School) - have accepted our invitation to serve on our Scientific Advisory Board.
- June 3, 2020 CeMM study reveals how a master regulator of gene transcription operates Using targeted protein degradation technology, researchers at CeMM, the Research Center for Molecular Medicine of the Austrian Academy of Sciences, set out to understand the primary role of a key regulator of transcription, the human Mediator complex.
- May 22, 2020 “Reverse engineering” autophagosome biogenesis reveals new protein interactions Scientists from Sascha Martens Lab at the Max Perutz Labs Vienna and their colleagues from the University of Berkeley (USA) have reconstituted the activity of key proteins involved in the growth of autophagosome precursors...
- April 20, 2020 Ubiquitin & Friends Symposium 2020, 14-15 May Due to the COVID-19 pandemic, this year’s Ubiquitin & Friends Symposium will take place virtually via Zoom on 14th and 15th of May 2020, with an exciting program and a stellar line-up of invited speakers. Registration is open until 5 May 2020.
- March 12, 2020 Layered Liquids – reaction chambers for gene regulation A marvel of complexity, the nucleus is the command center of the cell – harboring information, codes and controlled access. But different from man-made command centers, the nuclear interior looks chaotic to the eye of a scientist…
- December 5, 2019 Funding for a Special Research Program in Targeted Protein Degradation The Austrian Science Fund has awarded one of the prestigious Special Research Program (SFB) grants to a consortium of scientists in Vienna and Mainz to unravel mechanisms of targeted protein degradation.