July 7, 2023
Cryo-EM structure of the chain-elongating E3 ubiquitin ligase UBR5
Zuzana Hodakova, David Haselbach (IMP) and their collaborators used cryo-electron microscopy to analyse the structure of the enzyme UBR5. Difficult to work on due to its size, UBR5 is important due to its role in marking proteins for degradation. Their findings were now published in EMBO Journal.
See the IMP News for an interview with Zuzana Hodakova and David Haselbach about their work on UBR5.
Zuzana Hodáková, Irina Grishkovskaya, Hanna L. Brunner, Derek L. Bolhuis, Katarina Belačić, Alexander Schleiffer, Harald Kotisch, Nicholas G. Brown, David Haselbach:
Cryo-EM structure of the chain-elongating E3 ubiquitin ligase UBR5.
EMBO Journal. 2023 July 6.