Program
Venue: Van Swieten Hall of the Medical University of Vienna
Address: Van-Swieten-Gasse 1a, 1090 Vienna (see here on the map).
The program starts in the morning of May 2nd, and ends in the afternoon of May 3rd, with an award ceremony for the best posters, the best short talk and the travel grant awardees.
A pdf version of the program will be available soon. Print-outs of the program will be available on-site at the symposium.
Thursday, 2 May 2024
| 08:00-09:00 | Registration and poster setup |
| 09:00-09:05 | Welcome & introduction |
| SESSION 1 | Quality control in cellular compartments |
| 09:05-09:35 | Elvan Böke (CRG, Barcelona) |
| Evading ageing: Mitochondrial and proteostatic adaptations in oocytes | |
| 09:35-09:50 | Greta Bernardo (University of Padova) |
| USP14 inhibition enhances Parkin-independent mitophagy in iNeurons | |
| 09:50-10:20 | Yogesh Kulathu (MRC PPU, University of Dundee) |
| | Regulation of ER homeostasis by UFMylation |
| 10:20-10:35 | João Diamantino (University of Duisburg-Essen) |
| | Protein homeostasis mechanisms at the Golgi apparatus |
10:35-11:05 | Coffee break |
| 11:05-11:20 | Dávid Hargitai (Eötvös Loránd University, Budapest) |
| Tethering deadlock: A novel cellular event jamming vesicular pathways | |
| 11:20-11:35 | Rudolf Pisa (Harvard Medical School, Boston) |
| Through thick and thin: How a thin membrane drives substrate selection during ER-Associated Degradation | |
| 11:35-12:10 | Flash talks 1 – odd poster numbers |
12:10-13:50 | Lunch with poster session 1 (odd numbers) |
| 13:50-14:00 | Group photo |
SESSION 2 | Degradation of protein aggregates |
| 14:00-14:30 | Rubén Fernández-Busnadiego (University Medical Center Göttingen) |
| Unravelling the structure of toxic protein aggregates in situ | |
| 14:30-14:45 | Cole Sitron (Max Planck Institute of Biochemistry, Martinsried) |
| α-synuclein aggregation enhances proteopathic seeding by disrupting ESCRT-III function | |
| 14:45-15:00 | Maria Gierisch (Karolinska Institute, Stockholm) |
| Stimulating degradation of neurodegeneration-associated proteins | |
| 15:00-15:30 | Konstanze Winklhofer (Ruhr University Bochum) |
| Linear ubiquitylation at the interface between protein quality control and innate immune signaling | |
15:30-16:00 | Coffee break |
| 16:00-16:15 | Luca Ferrari (Max Perutz Labs, Vienna) |
| Tau fibrils evade autophagy by excessive p62 coating and TAX1BP1 exclusion | |
16:15-16:30 | Alexander Buchberger (University of Würzburg) p97/VCP is required for piecemeal autophagy of aggresomes |
16:30-16:45 | Stefan Müller (Goethe University Frankfurt) Proximity-induced functionalization of PML shields TDP-43 from stress-mediated aggregation via SUMO-primed non-proteolytic ubiquitylation |
| 16:45-17:20 | Flash talks 2 – even poster numbers |
17:20-19:15 | Wine Reception sponsored by Proxygen with poster session 2 (even numbers) |
| 19:30 | Conference dinner at Stiegl Ambulanz |
Friday, 3 May 2024
| SESSION 3 | The dark side of protein ubiquitination |
| 09:00-09:30 | Yifat Merbl (Weizmann Institute of Science, Rehovot) |
| From proteasomal degradation to immune homeostasis | |
| 09:30-09:45 | Adam Fletcher (University of Glasgow) |
| New methodology for proteome-wide E3 activity profiling in living cells | |
| 09:45-10:15 | Fumiyo Ikeda (Osaka University) |
| The RBR ligase HOIL-1 in the regulation of aggregates and inflammation | |
10:15-10:30 | Arno Alpi (Max Planck Institute of Biochemistry, Martinsried) |
| Non-canonical substrate recognition by the human WDR26-CTLH E3 ligase regulates prodrug metabolism | |
| 10:30-11:00 | Coffee break |
| SESSION 4 | E3 ligases in action |
| 11:00-11:15 | Julio Liu (University of Copenhagen) |
| Concerted SUMO-targeted ubiquitin ligase activities of TOPORS and RNF4 are essential for stress management and cell proliferation | |
11:15-11:30 | Rebeca Gogova (IMP, Vienna) |
| Control of HUWE1 by regulated intracellular trafficking | |
11:30-11:45 | Valentina Budroni (Max Perutz Labs, Vienna) |
| Multiple ubiquitin ligases protect human genome integrity by targeting cancer-associated APOBEC3 deaminases for degradation | |
11:45-12:00 | Jakub Luptak (MRC LMB, Cambridge) |
| Rethinking the role of E2 enzymes in TRIM21 driven ubiquitination | |
12:00-13:00 | Lunch break |
| SESSION 5 | UPS and emerging tools |
| 13:00-13:30 | Dan Finley (Harvard Medical School, Boston) |
| An endogenous inhibitor of the proteasome | |
| 13:30-13:45 | Katie Thomas (The Institute of Cancer Research, London) |
| Exploring the SAR of cyclin K degraders | |
| 13:45-14:00 | Evmorfia Dalietou (CMD, University of Oxford) |
| Towards PROTAC handle discovery for E3 Ligase KLHL12 | |
14:00-14:15 | Alejandro Rojas-Fernandez (Austral University of Chile, Valdivia) Specific proteolysis mediated by a p97-directed PROTAC |
| 14:15-14:45 | Andreas Martin (University of California, Berkeley) Conformation-specific proteasome binding of the thioredoxin-like protein TXNL1 |
14:45-15:00 | Award ceremony & Closing remarks |