Program
Venue: Van Swieten Saal of the Medical University of Vienna
Address: Van-Swieten-Gasse 1a, 1090 Vienna (see here on the map).
The program below might be still subject to minor changes. A pdf version for download will be available soon.
Print-outs of the program will be available on-site at the symposium.
Thursday, 8 May 2025
| 08:00-09:00 | Registration and poster setup |
| 09:00-09:05 | Welcome & introduction |
| SESSION 1 | UPS / Cellular Quality Control |
| 09:05-09:35 | Manu Hegde (MRC Laboratory of Molecular Biology, Cambridge) |
| Cellular mechanisms to counteract proteome imbalance | |
| 09:35-09:50 | Stefano Giandomenico (MPI for Brain Research, Frankfurt) |
| A developmentally-controlled adaptive regulator linking proteasome function and RNA biogenesis | |
| 09:50-10:20 | Andrea Musacchio (MPI for Molecular Physiology, Dortmund) |
| | Chromosome alignment and its feedback control |
| 10:20-10:35 | Emma Fink (Dana–Farber Cancer Institute, Boston) |
| | CRL5DFAC is a newly annotated E3 ubiquitin ligase that controls intracellular cysteine levels through the cystine-regulated degradation of CDO |
10:35-11:05 | Coffee break |
| 11:05-11:35 | Gabriel Lander (Scripps Research, San Diego) |
| Viewing Cereblon from an allosteric angle | |
| 11:35-11:50 | Zuzana Hodakova (IMP, Vienna) |
| Structure of the E3 HERC1 reveals substrate recognition mechanisms and a novel PCNA interaction | |
11:50-12:20 | Virginia De Cesare (University of Dundee) |
| E2s that behave differently: the UBE2Q1 non-canonical ubiquitylation machinery | |
| 12:20-12:50 | Flash talks 1 – odd poster numbers |
12:50-14:20 | Lunch with poster session 1 (odd numbers) |
| 14:20-14:30 | Group photo |
SESSION 2 | Autophagy / Organellar Quality Control |
| 14:30-15:00 | Sylvie Urbe (University of Liverpool) |
| Diverse routes to mitophagy governed by ubiquitylation and mitochondrial import | |
15:00-15:15 | Chun Guo (University of Sheffield) |
| Dissecting the Role of SUMOylation and deSUMOylation in Hypoxia-induced Mitophagy | |
| 15:15-15:30 | Elias Adriaenssens (Max Perutz Labs, Vienna) |
| How selective autophagy begins: two pathways, one goal | |
15:30-16:00 | Coffee break |
| 16:00-16:15 | Angelina Gross (BOKU University, and GMI, Vienna) |
| Autophagy regulation through stress-dependent plasticity of the Atg1/ULK kinase complex | |
16:15-16:30 | Gerhard Seisenbacher (IRB Barcelona) Regulation of selective endocytosis by the Hog1 Stress-activated Protein Kinase upon osmostress |
| 16:30-17:00 | Flash talks 2 – even poster numbers |
17:00-18:15 | Poster session 2 (even numbers) |
| 18:25 | Departure to conference dinner venue: Heuriger Maly |
Friday, 9 May 2025
| SESSION 3 | Tools |
| 09:00-09:30 | Hidde Ploegh (Boston Children’s Hospital) |
| Targeting E2-family enzymes with nanobodies | |
| 09:30-10:00 | Ilaria Piazza (MDC, Berlin, and Karolinska Institute, Stockholm) |
| Decoding proteostasis through proteome-wide biophysics | |
| 10:00-10:15 | Leo Kiss (MPI of Biochemistry, Martinsried) |
| Deciphering the Ubiquitin Degradation Code | |
| 10:15-10:45 | Coffee break |
| SESSION 4 | Ageing and Disease |
| 10:45-11:15 | Judith Frydman (Stanford University) |
| Chaperonin mediated protein folding in health and disease | |
11:15-11:45 | Della David (Babraham Institute, Cambridge) |
| Targeting protein aggregation to promote healthy aging | |
11:45-12:00 | Frédéric Ebtein (CNRS, INSERM, Nantes University) |
| Early neurogenesis restricts 26S proteasome function: a key vulnerability exploited by proteasome variants to drive neurodevelopmental disorders | |
12:00-12:15 | Jörg Tatzelt (Ruhr University Bochum) |
| Ubiquitination of a-synuclein interferes with the formation of seeding-competent fibrils | |
12:15-12:30 | Rahul Samant (Babraham Institute, Cambridge) |
| Divergence in post-ubiquitylation proteostasis strategies underpins the stress resilience of senescent human cells | |
12:30-13:30 | Lunch break |
| SESSION 5 | Signalling |
| 13:30-13:45 | Angela Lauriola (University of Verona) |
| The E3 ligase RNF32 controls NF-κB signalling in intestinal stem cells | |
| 13:45-14:00 | Thomas Mercer (Genentech, San Francisco) |
| Ubiquitin Phosphoserine 65 is a Novel Epigenetic Mark Implicated in Parkinson’s Disease | |
| 14:00-14:15 | Caroline Schätz (CeMM, Vienna) |
| Mechanism of Action of Selective Estrogen Receptor Degraders | |
14:15-14:45 | Steven Spoel (University of Edinburgh) Ubiquitin chains as physical platforms for cell signalling and immunity |
14:45-15:00 | Award ceremony & Closing remarks |