Program
Venue: Van Swieten Saal of the Medical University of Vienna
Address: Van-Swieten-Gasse 1a, 1090 Vienna (see here on the map).
You can download the Program Booklet as pdf here. Print-outs of the program will be available on-site at the symposium.
Thursday, 2 May 2024
| 08:00-09:00 | Registration and poster setup |
| 09:00-09:05 | Welcome & introduction |
| SESSION 1 | Quality control in cellular compartments |
| 09:05-09:35 | Elvan Böke (CRG, Barcelona) |
| Evading ageing: Mitochondrial and proteostatic adaptations in oocytes | |
| 09:35-09:50 | Greta Bernardo (University of Padova) |
| USP14 inhibition enhances Parkin-independent mitophagy in iNeurons | |
| 09:50-10:20 | Yogesh Kulathu (MRC PPU, University of Dundee) |
| | Regulation of ER homeostasis by UFMylation |
| 10:20-10:35 | João Diamantino (University of Duisburg-Essen) |
| | Protein homeostasis mechanisms at the Golgi apparatus |
10:35-11:05 | Coffee break |
| 11:05-11:20 | Dávid Hargitai (Eötvös Loránd University, Budapest) |
| Tethering deadlock: A novel cellular event jamming vesicular pathways | |
| 11:20-11:35 | Rudolf Pisa (Harvard Medical School, Boston) |
| Through thick and thin: How a thin membrane drives substrate selection during ER-Associated Degradation | |
| 11:35-12:10 | Flash talks 1 – odd poster numbers |
12:10-13:50 | Lunch with poster session 1 (odd numbers) |
| 13:50-14:00 | Group photo |
SESSION 2 | Degradation of protein aggregates |
| 14:00-14:30 | Rubén Fernández-Busnadiego (University Medical Center Göttingen) |
| Unravelling the structure of toxic protein aggregates in situ | |
| 14:30-14:45 | Cole Sitron (Max Planck Institute of Biochemistry, Martinsried) |
| α-synuclein aggregation enhances proteopathic seeding by disrupting ESCRT-III function | |
| 14:45-15:00 | Maria Gierisch (Karolinska Institute, Stockholm) |
| Stimulating degradation of neurodegeneration-associated proteins | |
| 15:00-15:30 | Konstanze Winklhofer (Ruhr University Bochum) |
| Linear ubiquitylation at the interface between protein quality control and innate immune signaling | |
15:30-16:00 | Coffee break |
| 16:00-16:15 | Luca Ferrari (Max Perutz Labs, Vienna) |
| Tau fibrils evade autophagy by excessive p62 coating and TAX1BP1 exclusion | |
16:15-16:30 | Alexander Buchberger (University of Würzburg) p97/VCP is required for piecemeal autophagy of aggresomes |
16:30-16:45 | Stefan Müller (Goethe University Frankfurt) Proximity-induced functionalization of PML shields TDP-43 from stress-mediated aggregation via SUMO-primed non-proteolytic ubiquitylation |
| 16:45-17:20 | Flash talks 2 – even poster numbers |
17:20-19:15 | Wine Reception sponsored by Proxygen with poster session 2 (even numbers) |
| 19:30 | Conference dinner at Stiegl Ambulanz |
Friday, 3 May 2024
| SESSION 3 | The dark side of protein ubiquitination |
| 09:00-09:30 | Yifat Merbl (Weizmann Institute of Science, Rehovot) |
| From proteasomal degradation to immune homeostasis | |
| 09:30-09:45 | Adam Fletcher (University of Glasgow) |
| New methodology for proteome-wide E3 activity profiling in living cells | |
| 09:45-10:15 | Fumiyo Ikeda (Osaka University) |
| The RBR ligase HOIL-1 in the regulation of aggregates and inflammation | |
10:15-10:30 | Arno Alpi (Max Planck Institute of Biochemistry, Martinsried) |
| Non-canonical substrate recognition by the human WDR26-CTLH E3 ligase regulates prodrug metabolism | |
| 10:30-11:00 | Coffee break |
| SESSION 4 | E3 ligases in action |
| 11:00-11:15 | Julio Liu (University of Copenhagen) |
| Concerted SUMO-targeted ubiquitin ligase activities of TOPORS and RNF4 are essential for stress management and cell proliferation | |
11:15-11:30 | Rebeca Gogova (IMP, Vienna) |
| Control of HUWE1 by regulated intracellular trafficking | |
11:30-11:45 | Valentina Budroni (Max Perutz Labs, Vienna) |
| Multiple ubiquitin ligases protect human genome integrity by targeting cancer-associated APOBEC3 deaminases for degradation | |
11:45-12:00 | Jakub Luptak (MRC LMB, Cambridge) |
| Rethinking the role of E2 enzymes in TRIM21 driven ubiquitination | |
12:00-13:00 | Lunch break |
| SESSION 5 | UPS and emerging tools |
| 13:00-13:30 | Dan Finley (Harvard Medical School, Boston) |
| An endogenous inhibitor of the proteasome | |
| 13:30-13:45 | Katie Thomas (The Institute of Cancer Research, London) |
| Exploring the SAR of cyclin K degraders | |
| 13:45-14:00 | Evmorfia Dalietou (CMD, University of Oxford) |
| Towards PROTAC handle discovery for E3 Ligase KLHL12 | |
14:00-14:15 | Alejandro Rojas-Fernandez (Austral University of Chile, Valdivia) Specific proteolysis mediated by a p97-directed PROTAC |
| 14:15-14:45 | Andreas Martin (University of California, Berkeley) Conformation-specific proteasome binding of the thioredoxin-like protein TXNL1 |
14:45-15:00 | Award ceremony & Closing remarks |