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2024A multivalent adaptor mechanism drives the nuclear import of proteasomesbioRxivBrunner HL, Kalis RW, Grundmann L, Hodáková Z, Koskova Z, Grishkovskaya I, de Almeida M, Hinterndorfer M, Höfflin S, Andersch F, Kotisch H, Dickmanns A, Cuylen-Häring S, Zuber J, Haselbach DGo to publication →
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2024Cross-species interactome analysis uncovers a conserved selective autophagy mechanism for protein quality control in plantsbioRxivSánchez de Medina Hernández V, Nava García MM, Clavel M, Papareddy RK, Andreev VI, Mathur V, Mohseni A, García-León M, Gao P, de la Concepción JC, Picchianti L, Grujic N, Kobylinska R, Abdrakhmanov A, Duvergé H, Anand G, Leibrock G, Bianchi A, Raffeiner M, Crawford TC, Argirò L, Matuszkiewicz M, Wun CL, Kanne JV, Meinhart A, Roitinger E, Bäurle I, Kang BH, Petersen M, Üstün S, Kulathu Y, Clausen T, Ramundo S, Dagdas YGo to publication →
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2024Tau fibrils evade autophagy by excessive p62 coating and TAX1BP1 exclusionScience AdvancesFerrari L, Bauer B, Qiu Y, Schuschnig M, Klotz S, Anrather D, Juretschke T, Beli P, Gelpi E, Martens SGo to publication →
2024Guardian ubiquitin E3 ligases target cancer-associated APOBEC3 deaminases for degradation to promote human genome integritybioRxivSchwartz I, Budroni V, Meyenberg M, Hornegger H, Hacker K, Schwartz S, Hodakova Z, Grabarczyk DB, Ehrmann JF, Scinicariello S, Haselbach D, Menche J, Clausen T, Karagöz GE, Versteeg GAGo to publication →
2024A RabGAP negatively regulates plant autophagy and immune traffickingCurrent BiologyYuen ELH, Leary AY, Clavel M, Tumtas Y, Mohseni A, Zhao J, Picchianti L, Jamshidiha M, Pandey P, Duggan C, Cota E, Dagdas Y, Bozkurt TOGo to publication →
2024Endoplasmic reticulum: Monitoring and maintaining protein and membrane homeostasis in the endoplasmic reticulum by the unfolded protein responseInt J Biochem Cell BiolKettel P, Karagöz GEGo to publication →
2024TRIM52 is a primate-specific player in the DNA repair process under tight proteolytic control by a triad of giant E3 ligasesbioRxivShulkina A, Hacker K, Ehrmann JF, Budroni V, Mandlbauer A, Bock J, Grabarczk DB, Cochella L, Clausen T, Versteeg GAGo to publication →
2024Metabolic enzymes moonlight as selective autophagy receptors to protect plants against viral-induced cellular damagebioRxivClavel M, Bianchi A, Kobylinska R, Groh R, Ma J, Papareddy RK, Grujic N, Picchianti L, Stewart E, Schutzbier M, Stejskal K, de la Concepcion JC, Sanchez de Medina Hernandez V, Yoichek Y, Clauw P, Gunis J, Durnberger G, Muelders JC, Grimm A, Sedivy A, Erhardt M, Vyboishchikov V, Gao P, Lechner E, Vantard E, Jez J, Roitinger E, Genschik P, Kang BG, Dagdas YGo to publication →
2024Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cellsScienceOffensperger F, Tin G, Duran-Frigola M, Hahn E, Dobner S, Ende CWA, Strohbach JW, Rukavina A, Brennsteiner V, Ogilvie K, Marella N, Kladnik K, Ciuffa R, Majmudar JD, Field SD, Bensimon A, Ferrari L, Ferrada E, Ng A, Zhang Z, Degliesposti G, Boeszoermenyi A, Martens S, Stanton R, Müller AC, Hannich JT, Hepworth D, Superti-Furga G, Kubicek S, Schenone M, Winter GEGo to publication →
2024ATG8ylation of vacuolar membrane protects plants against cell wall damagebioRxivJulian J, Gao P, Del Chiaro A, De La Concepcion JC, Armengot L, Somssich M, Duverge H, Clavel M, Grujic N, Kobylinska R, Polivka I, Besten M, Dank C, Korbei B, Bachmair A, Coll NS, Sprakel J, Dagdas Y.Go to publication →
2024BIG enhances Arg/N-degron pathway-mediated protein degradation to regulate Arabidopsis hypoxia responses and suberin depositionPlant CellZhang H, Rundle C, Winter N, Miricescu A, Mooney BC, Bachmair A, Graciet E, Theodoulou FLGo to publication →
2024Targeted protein degradation via intramolecular bivalent gluesNatureHsia O*, Hinterndorfer M*, Cowan AD*, Iso K, Ishida T, Sundaramoorthy R, Nakasone MA, Imrichova H, Schätz C, Rukavina A, Husnjak K, Wegner M, Correa-Sáez A, Craigon C, Casement R, Maniaci C, Testa A, Kaulich M, Dikic I, Winter GE†, Ciulli A†Go to publication →
2023Sequestration of translation initiation factors in p62 condensatesCell ReportsDanieli A, Vucak G, Baccarini M, Martens SGo to publication →
2023Discovery of Molecular Glue Degraders via Isogenic Morphological ProfilingASC Chemical BiologyNg A, Offensperger F, Cisneros JA, Scholes NS, Malik M, Villanti L, Rukavina A, Ferrada E, Hannich JT, Koren A, Kubicek S, Superti-Furga G, Winter GEGo to publication →
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2023Optimized infrared photoactivatable ribonucleoside enhanced crosslinking and immunoprecipitation (IR-PAR-CLIP) protocol identifies novel IGF2BP3-interacting RNAs in colon cancer cells.RNAAnisimova AS, Karagöz GEGo to publication →
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2023SPOP targets the immune transcription factor IRF1 for proteasomal degradationeLifeSchwartz I, Vunjak M, Budroni V, Cantoran García A, Mastrovito M, Soderholm A, Hinterndorfer M, de Almeida M, Hacker K, Wang J, Froussios K, Jude J, Decker T, Zuber J, Versteeg GA.Go to publication →
2023p62 and NBR1 functions are dispensable for aggrephagy in mouse ESCs and ESC-derived neuronsLife Science AllianceTrapannone R, Romanov J, Martens SGo to publication →
2023Lipid saturation controls nuclear envelope functionNature Cell BiologyRomanauska A, Köhler AGo to publication →
2023The membrane surface as a platform that organizes cellular and biochemical processesDevelopmental CellLeonard TA, Loose M, Martens S Go to publication →
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2023HUWE1 controls tristetraprolin proteasomal degradation by regulating its phosphorylationeLifeScinicariello S, Söderholm A, Schäfer M, Shulkina A, Schwartz I, Hacker K, Gogova R, Kalis RW, Froussios K, Budroni V, Bestehorn A, Clausen T, Kovarik P, Zuber J, Versteeg GA.Go to publication →
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2023Advancing Targeted Protein Degradation via Multiomics Profiling and Artificial IntelligenceJournal of American Chemical SocietyDuran-Frigola* M, Cigler M, and Winter GE*Go to publication →
2023A molecular network of conserved factors keeps ribosomes dormant in the eggNatureLeesch F, Lorenzo-Orts L, Pribitzer C, Grishkovskaya I, Roehsner J, Chugunova A, Matzinger M, Roitinger E, Belačić K, Kandolf S, Lin TY, Mechtler K, Meinhart A, Haselbach D, Pauli AGo to publication →
2023E3-Specific Degrader Discovery by Dynamic Tracing of Substrate Receptor AbundanceJournal of American Chemical SocietyHanzl A, Barone E, Bauer S, Yue H, Nowak RP, Hahn E, Pankevich EV, Koren A, Kubicek S, Fischer ES, Winter GEGo to publication →
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2022Characterization of ATG8-Family Interactors by Isothermal Titration CalorimetryMethods in Molecular BiologyPicchianti L, Sedivy A, Dagdas YGo to publication →
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2022Site-selective photocatalytic functionalization of peptides and proteins at selenocysteineNature CommunicationsDowman LJ, Kulkarni SS, Alegre-Requena JV, Giltrap AM, Norman AR, Sharma A, Gallegos LC, Mackay AS, Welegedara AP, Watson EE, van Raad D, Niederacher G, Huhmann S, Proschogo N, Patel K, Larance M, Becker CFW, Mackay JP, Lakhwani G, Huber T, Paton RS, Payne RJGo to publication →
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2022Functional E3 ligase hotspots and resistance mechanisms to small-molecule degradersNature Chemical BiologyHanzl A, Casement R, Imrichova H, Hughes SJ, Barone E, Testa A, Bauer S, Wright J, Brand M, Ciulli A, Winter GEGo to publication →
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2022BacPROTACs mediate targeted protein degradation in bacteriaCellMorreale FE, Kleine S, Leodolter J, Junker S, Hoi DM, Ovchinnikov S, Okun A, Kley J, Kurzbauer R, Junk L, Guha S, Podlesainski D, Kazmaier U, Boehmelt G, Weinstabl H, Rumpel K, Schmiedel VM, Hartl M, Haselbach D, Meinhart A, Kaiser M, Clausen TGo to publication →
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2021E3 ubiquitin ligase RNF213 employs a non-canonical zinc finger active site and is allosterically regulated by ATPbioRxivAhel J, Fletcher A, Grabarczyk DB, Roitinger E, Deszcz L, Lehner A, Virdee S, Clausen TGo to publication →
2022Transcriptome, metabolome and suppressor analysis reveal an essential role for the ubiquitin-proteasome system in seedling chloroplast developmentBMC Plant BiologyTalloji P, Nehlin L, Hüttel B, Winter N, Černý M, Dufková H, Hamali B, Hanczaryk K, Novák J, Hermanns M, Drexler N, Eifler K, Schlaich N, Brzobohatý B, Bachmair AGo to publication →
2022Autophagy promotes programmed cell death and corpse clearance in specific cell types of the Arabidopsis root capCurrent BiologyFeng Q, De Rycke R, Dagdas Y, Nowack MKGo to publication →
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2022A yeast-based functional assay to study plant N-degron – N-recognin interactionsFrontiers in Plant ScienceKozlic A, Winter N, Telser T, Reimann J, Rose K, Nehlin L, Berckhan S, Sharma G, Dambire C, Boeckx T, Holdsworth MJ, Bachmair AGo to publication →
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2021Cellular control of protein turnover via modification of the amino terminusInternational Journal of Molecular SciencesWinter N, Novatchkova M and Bachmair AGo to publication →
2021Proteome-wide identification of NEDD8 modification sites reveals distinct proteomes for canonical and atypical NEDDylationCell ReportsLobato-Gil S, Heidelberger JB, Maghames C, Bailly A, Brunello L, Rodriguez MS, Beli P*, Xirodimas DP* (*co-corresponding authors)Go to publication →
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2020Rational discovery of molecular glue degraders via scalable chemical profilingNature Chemical BiologyMayor-Ruiz C, Bauer S, Brand M, Kozicka Z, Siklos M, Imrichova H, Kaltheuner IH, Hahn E, Seiler K, Koren A, Petzold G, Fellner M, Bock C, Müller AC, Zuber J, Geyer M, Thomä NH, Kubicek S, Winter GEGo to publication →
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2020Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanismeLifeAhel J, Lehner A, Vogel A, Schleiffer A, Meinhart A, Haselbach D, Clausen TGo to publication →
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2020A PI3K-WIPI2 positive feedback loop allosterically activates LC3 lipidation in autophagyJournal of Cell BiologyFracchiolla D, Chang C, Hurley JH, Martens SGo to publication →
2020Phase separation directs ubiquitination of gene-body nucleosomesNatureGallego LD, Schneider M, Mittal C, Romanauska A, Gudino Carrillo RM, Schubert T, Pugh BF, Köhler AGo to publication →
2020Highly Precise Protein Semisynthesis through Ligation–Desulfurization Chemistry in Combination with Phenacyl Protection of Native CysteinesMethods in Molecular BiologyMukherjee S, Matveenko M, Becker CFWGo to publication →
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2019Quiescence of Adult Mammalian Neural Stem Cells: A Highly Regulated RestNeuronUrbán N, Blomfield IM, Guillemot FGo to publication →
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2019MTHFD1 interaction with BRD4 links folate metabolism to transcriptional regulationNature GeneticsSdelci S, Rendeiro AF, Rathert P, You W, Lin JG, Ringler A, Hofstätter G, Moll HP, Gürtl B, Farlik M, Schick S, Klepsch F, Oldach M, Buphamalai P, Schischlik F, Májek P, Parapatics K, Schmidl C, Schuster M, Penz T, Buckley DL, Hudecz O, Imre R, Wang SY, Maric HM, Kralovics R, Bennett KL, Müller AC, Mechtler K, Menche J, Bradner JE, Winter GE, Klavins K, Casanova E, Bock C, Zuber J, Kubicek SGo to publication →
2019FIP200 Claw Domain Binding to p62 Promotes Autophagosome Formation at Ubiquitin CondensatesMolecular CellTurco E, Witt M, Abert C, Bock-Bierbaum T, Su MY, Trapannone R, Sztacho M, Danieli A, Shi X, Zaffagnini G, Gamper A, Schuschnig M, Fracchiolla D, Bernklau D, Romanov J, Hartl M, Hurley JH, Daumke O, Martens SGo to publication →
2019Structure of McsB, a protein kinase for regulated arginine phosphorylationNature Chemical BiologySuskiewicz MJ, Hajdusits B, Beveridge R, Heuck A, Vu LD, Kurzbauer R, Hauer K, Thoeny V, Rumpel K, Mechtler K, Meinhart A, Clausen TGo to publication →
2019Locus-Specific Knock-in of a degradable tag for target validation studiesMethods in Molecular BiologyBrand M, Winter GEGo to publication →
2019Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AMLCell Chemical BiologyBrand M, Jiang B, Bauer S, Donovan KA, Liang Y, Wang ES, Nowak RP, Yuan JC, Zhang T, Kwiatkowski N, Müller AC, Fischer ES, Gray NS, Winter GEGo to publication →
2019The Scope, Functions, and Dynamics of Posttranslational Protein ModificationsAnnu. Rev. Plant Biol.Millar AH, Heazlewood JL, Giglione C, Holdsworth MJ, Bachmair A, Schulze WXGo to publication →
2019Identification and characterization of cancer vulnerabilities via targeted protein degradationDrug Discov. Today Technol.Mayor-Ruiz C, Winter GEGo to publication →
2018The unfolded protein response and endoplasmic reticulum protein targeting machineries converge on the stress sensor IRE1eLifeAcosta-Alvear D, Karagöz GE, Fröhlich F, Li H, Walther TC, Walter PGo to publication →
2019Single Posttranslational Modifications in the Central Repeat Domains of Tau4 Impact its Aggregation and Tubulin BindingAngewandte Chemie International Ed.Ellmer D, Brehs M, Haj-Yahya M, Lashuel HA, Becker CFWGo to publication →
2018LZTR1 is a regulator of RAS ubiquitination and signalingScienceBigenzahn JW, Collu GM, Kartnig F, Pieraks M, Vladimer GI, Heinz LX, Sedlyarov V, Schischlik F, Fauster A, Rebsamen M, Parapatics K, Blomen VA, Müller AC, Winter GE, Kralovics R, Brummelkamp TR, Mlodzik M, Superti-Furga GGo to publication →
2018Native chemical ligation in protein synthesis and semi-synthesisChem. Soc. Rev.Conibear AC, Watson EE, Payne RJ, Becker CFWGo to publication →
2019Distinct branches of the N-end rule pathway modulate the plant immune responseNew PhytologistVicente J, Mendiondo GM, Pauwels J, Pastor V, Izquierdo Y, Naumann C, Movahedi M, Rooney D, Gibbs DJ, Smart K, Bachmair A, Gray JE, Dissmeyer N, Castresana C, Ray RV, Gevaert K, Holdsworth MJGo to publication →
2018The inner nuclear membrane is a metabolically active territory that generates nuclear lipid dropletsCellRomanauska A, Köhler AGo to publication →
2018Host autophagy machinery is diverted to the pathogen interface to mediate focal defense responses against the Irish potato famine pathogeneLifeDagdas YF*, Pandey P*, Tumtas Y, Sanguankiattichai N, Belhaj K, Duggan C, Leary AY, Segretin ME, Contreras MP, Savage Z, Khandare VS, Kamoun S, Bozkurt TOGo to publication →
2018Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48Nature CommunicationsVelimezi G, Robinson-Garcia L, Muñoz-Martínez F, Wiegant WW, Ferreira da Silva J, Owusu M, Moder M, Wiedner M, Rosenthal SB, Fisch KM, Moffat J, Menche J, van Attikum H, Jackson SP, Loizou JIGo to publication →
2018Targetable BET proteins- and E2F1-dependent transcriptional program maintains the malignancy of glioblastomaProc. Natl. Acad. Sci. USAXu L, Chen Y, Mayakonda A, Koh L, Chong YK, Buckley DL, Sandanaraj E, Lim SW, Lin RY, Ke XY, Huang ML, Chen J, Sun W, Wang LZ, Goh BC, Dinh HQ, Kappei D, Winter GE, Ding LW, Ang BT, Berman BP, Bradner JE, Tang C, Koeffler HPGo to publication →
2018The dTAG system for immediate and target-specific protein degradationNature Chemical BiologyNabet B, Roberts JM, Buckley DL, Paulk J, Dastjerdi S, Yang A, Leggett AL, Erb MA, Lawlor MA, Souza A, Scott TG, Vittori S, Perry JA, Qi J, Winter GE, Wong KK, Gray NS, Bradner JEGo to publication →
2018p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damageNature CommunicationsBorisova ME, Voigt A, Tollenaere MAX, Sahu SK, Juretschke T, Kreim N, Mailand N, Choudhary C, Bekker-Jensen S, Akutsu M, Wagner SA, Beli PGo to publication →
2018Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligandsNature Chemical BiologyGechijian LN, Buckley DL, Lawlor MA, Reyes JM, Paulk J, Ott CJ, Winter GE, Erb MA, Scott TG, Xu M, Seo HS, Dhe-Paganon S, Kwiatkowski NP, Perry JA, Qi J, Gray NS, Bradner JEGo to publication →
2018Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc functionEMBO ReportsHeidelberger JB, Voigt A, Borisova ME, Petrosino G, Ruf S, Wagner SA, Beli PGo to publication →
2018Human tripartite motif protein 52 is required for cell context-dependent proliferationOncotargetBenke S, Agerer B, Haas L, Stöger M, Lercher A, Gabler L, Kiss I, Scinicariello S, Berger W, Bergthaler A, Obenauf AC, Versteeg GAGo to publication →
2018UFD-2 is an adaptor-assisted E3 ligase targeting unfolded proteinsNature CommunicationsHellerschmied D, Roessler M, Lehner A, Gazda L, Stejskal K, Imre R, Mechtler K, Dammermann A, Clausen TGo to publication →
2018Translation Termination Factor GSPT1 Is a Phenotypically Relevant Off-Target of Heterobifunctional Phthalimide DegradersACS Chem. Biol.Ishoey M, Chorn S, Singh N, Jaeger MG, Brand M, Paulk J, Bauer S, Erb MA, Parapatics K, Müller AC, Bennett KL, Ecker GF, Bradner JE, Winter GEGo to publication →
2018p62 filaments capture and present ubiquitinated cargos for autophagyEMBO JournalZaffagnini G, Savova A, Danieli A, Romanov J, Tremel S, Ebner M, Peterbauer T, Sztacho M, Trapannone R, Tarafder AK, Sachse C, Martens SGo to publication →
2018SUMO chain formation relies on the amino-terminal region of SUMO conjugating enzyme and has dedicated substrates in plantsBiochemical J. Tomanov, K., Nehlin, L., Ziba, I., Bachmair, A. Go to publication →
2018Acute Pharmacologic Degradation of a Stable Antigen Enhances Its Direct Presentation on MHC Class I MoleculesFront. Immunol.Moser SC, Voerman JSA, Buckley DL, Winter GE, Schliehe CGo to publication →
2018Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradationNat. Chem. Biol.Olson CM, Jiang B, Erb MA, Liang Y, Doctor ZM, Zhang Z, Zhang T, Kwiatkowski N, Boukhali M, Green JL, Haas W, Nomanbhoy T, Fischer ES, Young RA, Bradner JE, Winter GE, Gray NSGo to publication →
2017Repair of UV-Induced DNA Damage Independent of Nucleotide Excision Repair Is Masked by MUTYHMol. CellMazouzi A, Battistini F, Moser SC, Ferreira da Silva, Wiedner M, Owusu M, Lardeau C-H, Ringler A, Weil B, Neesen J, Orozco M, Kubicek S, Loizou JIGo to publication →
2017Parallel genome-wide screens identify a synthetic viable interaction between the BLM helicase complex and Fanconi anemiaNat. Commun.Moder M, Velimezi G, Owusu M, Mazouzi A, Wiedner M, Ferreira da Silva J, Robinson-Garcia L, Schischlik F, Slavkovsky R, Kralovics R, Schuster M, Bock C, Ideker T, Jackson SP, Menche J, Loizou JIGo to publication →
2017An unfolded protein-induced conformational switch activates mammalian IRE1 eLifeKaragöz GE, Acosta-Alvear D, Nguyen HT, Lee CP, Chu F, Walter PGo to publication →
2017MELK is not necessary for the proliferation of basal-like breast cancer cellseLifeHuang HT, Seo HS, Zhang T, Wang Y, Jiang B, Li Q, Buckley DL, Nabet B, Roberts JM, Paulk J, Dastjerdi S, Winter GE, McLauchlan H, Moran J, Bradner JE, Eck MJ, Dhe-Paganon S, Zhao JJ, Gray NSGo to publication →
2017Long-range allosteric regulation of the human 26S proteasome by 20S proteasome-targeting cancer drugsNat. Commun.Haselbach D , Schrader J, Lambrecht F, Henneberg F, Chari A, Stark HGo to publication →
2017Semisynthetic prion protein (PrP) variants carrying glycan mimics at position 181 and 197 do not form fibrilsChem. Sci.Araman C, Thompson RE, Wang S, Hackl S, Payne RJ, Becker CFWGo to publication →
2017BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 RecruitmentMol. CellWinter GE, Mayer A, Buckley DL, Erb MA, Roderick JE, Vittori S, Reyes JM, di Iulio J, Souza A, Ott CJ, Roberts JM, Zeid R, Scott TG, Paulk J, Lachance K, Olson CM, Dastjerdi S, Bauer S, Lin CY, Gray NS, Kelliher MA, Churchman LS, Bradner JEGo to publication →
2017Transcription control by the ENL YEATS domain in acute leukaemiaNatureErb MA, Scott TG, Li BE, Xie H, Paulk J, Seo HS, Souza A, Roberts JM, Dastjerdi S, Buckley DL, Sanjana NE, Shalem O, Nabet B, Zeid R, Offei-Addo NK, Dhe-Paganon S, Zhang F, Orkin SH, Winter GE, Bradner JEGo to publication →
2016Mechanism of cargo-directed Atg8 conjugation during selective autophagyeLifeFracchiolla D, Sawa-Makarska J, Zens B, Ruiter A, Zaffagnini G, Brezovich A, Romanov J, Runggatscher K, Kraft C, Zagrovic B, Martens SGo to publication →
2016Arginine phosphorylation marks proteins for degradation by a Clp proteaseNatureTrentini DB, Suskiewicz MJ, Heuck A, Kurzbauer R, Deszcz L, Mechtler K, Clausen TGo to publication →
2016Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin LigationMol. CellYamaguchi M, VanderLinden R, Weissmann F, Qiao R, Dube P, Brown NG, Haselbach D, Zhang W, Sidhu SS, Peters JM, Stark H, Schulman BAGo to publication →
2016Structural Basis of Host Autophagy-related Protein 8 (ATG8) Binding by the Irish Potato Famine Pathogen Effector Protein PexRD54J. Biol. Chem.Maqbool A, Hughes RK, Dagdas YF, Tregidgo N, Zess E, Belhaj K, Round A, Bozkurt TO, Kamoun S, Banfield MJGo to publication →
2016Return to quiescence of mouse neural stem cells by degradation of a proactivation proteinScienceUrbán N, van den Berg DL, Forget A, Andersen J, Demmers JA, Hunt C, Ayrault O, Guillemot FGo to publication →
2016Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/CCellBrown NG, VanderLinden R, Watson ER, Weissmann F, Ordureau Am Wu KP, Zhang W, Yu S, Mercedi PY, Harrison JS, Davidson IF, Qiao R, Lu Y, Dube P, Brunner MR, Grace CR, Miller DJ, Haselbach D, Jarvis MA, Yamaguchi M, Yanisheski D, Petzold G, Sidhu SS, Kuhlmann B, Kirschner MW, Harper JW, Peters JM, Stark H, Schulman BAGo to publication →
2016Mechanism of APC/CCDC20 activation by mitotic phosphorylationProc. Natl. Acad. Sci. USAQiao R, Weissmann F, Yamaguchi M, Brown NG, VanderLinden R, Imre R, Jarvis MA, Brunner MR, Davidson IF, Litos G, Haselbach D , Mechtler K, Stark H, Schulman BA, Peters JMGo to publication →
2016An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptoreLifeDagdas YF*, Belhaj K*, Maqbool A, Chaparro-Garcia A, Pandey P, Petre B, Tabassum N, Cruz-Mireles N, Hughes RK, Sklenar J, Win J, Menke F, Findlay K, Banfield MJ, Kamoun S, Bozkurt TOGo to publication →
2015Oligomerization of p62 allows for selection of ubiquitinated cargo and isolation membrane during selective autophagyeLifeWurzer B, Zaffagnini G, Fracchiolla D, Turco E, Abert C, Romanov J, Martens SGo to publication →
2015ProteoPlex: stability optimization of macromolecular complexes by sparse-matrix screening of chemical spaceNat. MethodsChari A*, Haselbach D *, Kirves JM*, Ohmer J, Paknia E, Fischer N, Ganichkin O,Möller V, Frye JJ, Petzold G, Jarvis M, Tietzel M, Grimm C, Peters JM, Schulman BA, Tittmann K, Markl J, Fischer U, Stark H. (*equal contribution)Go to publication →
2015DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradationScienceWinter GE, Buckley DL, Paulk J, Roberts JM, Souza A, Dhe-Paganon S, Bradner JEGo to publication →
2014The eukaryotic N-end rule pathway: conserved mechanisms and diverse functionsTrends in Cell Biol.Gibbs DJ, Bacardit J, Bachmair A, Holdsworth MJGo to publication →
2014Cargo binding to Atg19 unmasks additional Atg8 binding sites to mediate membrane–cargo apposition during selective autophagyNat. Cell Biol.Sawa-Makarska J, Abert C, Romanov J, Zens B, Ibiricu I, Martens SGo to publication →
2014Hsp90-Tau complex reveals molecular basis for specificity in chaperone actionCellKaragöz GE, Duarte AM, Akoury E, Ippel H, Biernat J, Morán Luengo T, Radli M, Didenko T, Nordhues BA, Veprintsev DB, Dickey CA, Mandelkow E, Zweckstetter M, Boelens R, Madl T, Rüdiger SGGo to publication →
2014Nitric oxide sensing in plants is mediated by proteolytic control of group VII ERF transcription factorsMol. CellGibbs DJ, Md Isa N, Movahedi M, Lozano-Juste J, Mendiondo GM, Berckhan S, Marín-de la Rosa N, Vicente Conde J, Sousa Correia C, Pearce SP, Bassel GW, Hamali B, Talloji P, Tomé DF, Coego A, Beynon J, Alabadí D, Bachmair A, León J, Gray JE, Theodoulou FL, Holdsworth MJGo to publication →
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