2020Wnt/beta-catenin signalling is dispensable for adult neural stem cell homeostasis and activationbioRxivAustin SHL, Harris L, Paun O, Rigo P, Guillemot F, Urbán NGo to publication →
2021Proteome-wide identification of NEDD8 modification sites reveals distinct proteomes for canonical and atypical NEDDylationCell Rep.Lobato-Gil S, Heidelberger JB, Maghames C, Bailly A, Brunello L, Rodriguez MS, Beli P*, Xirodimas DP* (*co-corresponding authors)Go to publication →
2020Reconstitution of autophagosome nucleation defines Atg9 vesicles as seeds for membrane formationScienceSawa-Makarska J, Baumann V, Coudevylle N, von Bülow S, Nogellova V, Abert C, Schuschnig M, Graef M, Hummer G, Martens SGo to publication →
2020A cross-kingdom conserved ER-phagy receptor maintains endoplasmic reticulum homeostasis during stresseLifeStephani M, Picchianti L, Gajic A, Beveridge R, Skarwan R, Sanchez de Medina Hernandez V, Mohseni A, Clavel M, Zeng Y, Naumann C, Matuszkiewicz M, Turco E, Loefke C, Li B, Durnberger G, Schutzbier M, Chen HT, Abdrakhmanov A, Savova A, Chia KS, Djamei A, Schaffner I, Abel S, Jiang L, Mechtler K, Ikeda F, Martens S, Clausen T, Dagdas YGo to publication →
2020Rational discovery of molecular glue degraders via scalable chemical profilingNature Chemical BiologyMayor-Ruiz C, Bauer S, Brand M, Kozicka Z, Siklos M, Imrichova H, Kaltheuner IH, Hahn E, Seiler K, Koren A, Petzold G, Fellner M, Bock C, Müller AC, Zuber J, Geyer M, Thomä NH, Kubicek S, Winter GEGo to publication →
2020Native Mass Spectrometry Can Effectively Predict PROTAC EfficacyACS Central ScienceBeveridge R, Kessler D, Rumpel K, Ettmayer P, Meinhart A, Clausen TGo to publication →
2020Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanismeLifeAhel J, Lehner A, Vogel A, Schleiffer A, Meinhart A, Haselbach D, Clausen TGo to publication →
2020Quantifying the heterogeneity of macromolecular machines by mass photometryNature CommunicationsSonn-Segev A, Belacic K, Bodrug T, Young G, VanDerLindern R, Schulman BA, Schimpf J, Friedrich T, Dip PV, Schwartz TU, Bauer B, Peters JM, Struwe WB, Benesch JLP, Brown NG*, Haselbach D*, Kukura P* (*co-corresponding authors)Go to publication →
2020The linear ubiquitin chain assembly complex generates heterotypic ubiquitin chainsbioRxivRodriguez Carvajal A, Gomez Diaz C, Vogel A, Sonn-Segev A, Schodl K, Deszcz L, Orban-Nemeth Z, Sakamoto S, Mechtler K, Kukura P, Clausen T, Haselbach D, Ikeda FGo to publication →
2020Selective Mediator dependence of cell-type-specifying transcriptionNature GeneticsJaeger MG, Schwalb B, Mackowiak SD, Velychko T, Hanzl A, Imrichova H, Brand M, Agerer B, Chorn S, Nabet B, Ferguson FM, Müller AC, Bergthaler A, Gray NS, Bradner JE, Bock C, Hnisz D, Cramer P, Winter GEGo to publication →
2020A PI3K-WIPI2 positive feedback loop allosterically activates LC3 lipidation in autophagyJournal of Cell BiologyFracchiolla D, Chang C, Hurley JH, Martens SGo to publication →
2020The Irish potato famine pathogen subverts host vesicle trafficking to channel starvation-induced autophagy to the pathogen interfacebioRxivPandey P, Leary AY, Tümtas Y, Savage Z, Dagvadorj B, Tan E, Khandare V, Duggan C, Yusunov T, Madalinski M, Mirkin FG, Schornack S, Dagdas Y, Kamoun S, Bozkurt TOGo to publication →
2020Phase separation directs ubiquitination of gene-body nucleosomesNatureGallego LD, Schneider M, Mittal C, Romanauska A, Gudino Carrillo RM, Schubert T, Pugh BF, Köhler AGo to publication →
2020Highly Precise Protein Semisynthesis through Ligation–Desulfurization Chemistry in Combination with Phenacyl Protection of Native CysteinesMethods in Mol. Biol.Mukherjee S, Matveenko M, Becker CFWGo to publication →
2020EXO70D isoforms mediate selective autophagic degradation of Type-A ARR proteins to regulate cytokinin sensitivitybioRxivAcheampong AK, Shanks C, Chang CY, Schaller E, Dagdas Y, Kieber JJGo to publication →
2020Autophagy mediates temporary reprogramming and dedifferentiation in plant somatic cellsEMBO J.Rodriguez E, Chevalier J, Olsen J, Ansbøl J, Kapousidou V, Zuo Z, Svenning S, Loefke C, Koemeda S, Drozdowskyj PS, Jez J, Durnberger G, Kuenzl F, Schutzbier M, Mechtler K, Ebstrup EN, Lolle S, Dagdas Y*, Petersen M*Go to publication →
2020Targeted protein degradation: current and future challengesCurr. Opin. Chem. Biol. Hanzl A. Winter GEGo to publication →
2019Quiescence of Adult Mammalian Neural Stem Cells: A Highly Regulated RestNeuronUrbán N, Blomfield IM, Guillemot FGo to publication →
2019The RNA-binding ubiquitin ligase MKRN1 functions in ribosome-associated quality control of poly(A) translationGenome Biol.Hildebrandt A, Brüggemann M, Rücklé C, Boerner S, Heidelberger JB, Busch A, Hänel H, Voigt A, Möckel MM, Ebersberger S, Scholz A, Dold A, Schmid T, Ebersberger I, Roignant JY, Zarnack K, König J, Beli PGo to publication →
2019Id4 promotes the elimination of the pro-activation factor Ascl1 to maintain quiescence of adult hippocampal stem cellseLifeBlomfield IM, Rocamonde B, Masdeu MDM, Mulugeta E, Vaga S, van den Berg DL, Huillard E, Guillemot F, Urbán NGo to publication →
2019Labeling and Natural Post-Translational Modification of Peptides and Proteins via Chemoselective Pd-Catalyzed Prenylation of CysteineJ. Am. Chem. Soc.Schlatzer T, Kriegesmann J, Schröder H, Trobe M, Lembacher-Fadum C, Santner S, Kravchuk AV, Becker CFW, Breinbauer RGo to publication →
2019Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding siteProc. Natl. Acad. Sci. USAWatson ER, Grace CRR, Zhang W, Miller DJ, Davidson IF, Prabu JR, Yu S, Bolhuis DL, Kulko ET, Vollrath R, Haselbach D, Stark H, Peters JM, Brown NG, Sidhu SS, Schulman BAGo to publication →
2019N-terminal β-strand underpins biochemical specialization of an ATG8 isoformPLoS Biol.Zess EK, Jensen C, Cruz-Mireles N, De la Concepcion JC, Sklenar J, Stephani M, Imre R, Roitinger E, Hughes R, Belhaj K, Mechtler K, Menke FLH, Bozkurt T, Banfield MJ, Kamoun S, Maqbool A, Dagdas YFGo to publication →
2019Plasticity of the cullin-RING ligase repertoire shapes sensitivity to ligand-induced protein degradationMol. CellMayor-Ruiz C, Jaeger MG, Bauer S, Brand M, Sin C, Hanzl A, Mueller AC, Menche J, Winter GEGo to publication →
2019A repetitive acidic region contributes to the extremely rapid degradation of the cell-context essential protein TRIM52Scientific ReportsHacker K, Benke S, Agerer B, Scinicariello S, Budroni V, Versteeg GAGo to publication →
2019MTHFD1 interaction with BRD4 links folate metabolism to transcriptional regulationNature GeneticsSdelci S, Rendeiro AF, Rathert P, You W, Lin JG, Ringler A, Hofstätter G, Moll HP, Gürtl B, Farlik M, Schick S, Klepsch F, Oldach M, Buphamalai P, Schischlik F, Májek P, Parapatics K, Schmidl C, Schuster M, Penz T, Buckley DL, Hudecz O, Imre R, Wang SY, Maric HM, Kralovics R, Bennett KL, Müller AC, Mechtler K, Menche J, Bradner JE, Winter GE, Klavins K, Casanova E, Bock C, Zuber J, Kubicek SGo to publication →
2019FIP200 Claw Domain Binding to p62 Promotes Autophagosome Formation at Ubiquitin CondensatesMol. CellTurco E, Witt M, Abert C, Bock-Bierbaum T, Su MY, Trapannone R, Sztacho M, Danieli A, Shi X, Zaffagnini G, Gamper A, Schuschnig M, Fracchiolla D, Bernklau D, Romanov J, Hartl M, Hurley JH, Daumke O, Martens SGo to publication →
2019Structure of McsB, a protein kinase for regulated arginine phosphorylationNat. Chem. Biol.Suskiewicz MJ, Hajdusits B, Beveridge R, Heuck A, Vu LD, Kurzbauer R, Hauer K, Thoeny V, Rumpel K, Mechtler K, Meinhart A, Clausen TGo to publication →
2019Locus-Specific Knock-in of a degradable tag for target validation studiesMethods Mol. Biol.Brand M, Winter GEGo to publication →
2019Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AMLCell Chem. BiologyBrand M, Jiang B, Bauer S, Donovan KA, Liang Y, Wang ES, Nowak RP, Yuan JC, Zhang T, Kwiatkowski N, Müller AC, Fischer ES, Gray NS, Winter GEGo to publication →
2019The Scope, Functions, and Dynamics of Posttranslational Protein ModificationsAnnu. Rev. Plant Biol.Millar AH, Heazlewood JL, Giglione C, Holdsworth MJ, Bachmair A, Schulze WXGo to publication →
2019Identification and characterization of cancer vulnerabilities via targeted protein degradationDrug Discov. Today Technol.Mayor-Ruiz C, Winter GEGo to publication →
2018The unfolded protein response and endoplasmic reticulum protein targeting machineries converge on the stress sensor IRE1eLifeAcosta-Alvear D, Karagöz GE, Fröhlich F, Li H, Walther TC, Walter PGo to publication →
2019Single Posttranslational Modifications in the Central Repeat Domains of Tau4 Impact its Aggregation and Tubulin BindingAngew. Chem. Int. Ed.Ellmer D, Brehs M, Haj-Yahya M, Lashuel HA, Becker CFWGo to publication →
2018LZTR1 is a regulator of RAS ubiquitination and signalingScienceBigenzahn JW, Collu GM, Kartnig F, Pieraks M, Vladimer GI, Heinz LX, Sedlyarov V, Schischlik F, Fauster A, Rebsamen M, Parapatics K, Blomen VA, Müller AC, Winter GE, Kralovics R, Brummelkamp TR, Mlodzik M, Superti-Furga GGo to publication →
2018Native chemical ligation in protein synthesis and semi-synthesisChem. Soc. Rev.Conibear AC, Watson EE, Payne RJ, Becker CFWGo to publication →
2019Distinct branches of the N-end rule pathway modulate the plant immune responseNew Phytol.Vicente J, Mendiondo GM, Pauwels J, Pastor V, Izquierdo Y, Naumann C, Movahedi M, Rooney D, Gibbs DJ, Smart K, Bachmair A, Gray JE, Dissmeyer N, Castresana C, Ray RV, Gevaert K, Holdsworth MJGo to publication →
2018The inner nuclear membrane is a metabolically active territory that generates nuclear lipid dropletsCellRomanauska A, Köhler AGo to publication →
2018Host autophagy machinery is diverted to the pathogen interface to mediate focal defense responses against the Irish potato famine pathogeneLifeDagdas YF*, Pandey P*, Tumtas Y, Sanguankiattichai N, Belhaj K, Duggan C, Leary AY, Segretin ME, Contreras MP, Savage Z, Khandare VS, Kamoun S, Bozkurt TOGo to publication →
2018Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48Nat. Commun.Velimezi G, Robinson-Garcia L, Muñoz-Martínez F, Wiegant WW, Ferreira da Silva J, Owusu M, Moder M, Wiedner M, Rosenthal SB, Fisch KM, Moffat J, Menche J, van Attikum H, Jackson SP, Loizou JIGo to publication →
2018Targetable BET proteins- and E2F1-dependent transcriptional program maintains the malignancy of glioblastomaProc. Natl. Acad. Sci. USAXu L, Chen Y, Mayakonda A, Koh L, Chong YK, Buckley DL, Sandanaraj E, Lim SW, Lin RY, Ke XY, Huang ML, Chen J, Sun W, Wang LZ, Goh BC, Dinh HQ, Kappei D, Winter GE, Ding LW, Ang BT, Berman BP, Bradner JE, Tang C, Koeffler HPGo to publication →
2018The dTAG system for immediate and target-specific protein degradationNat. Chem. Biol.Nabet B, Roberts JM, Buckley DL, Paulk J, Dastjerdi S, Yang A, Leggett AL, Erb MA, Lawlor MA, Souza A, Scott TG, Vittori S, Perry JA, Qi J, Winter GE, Wong KK, Gray NS, Bradner JEGo to publication →
2018p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damageNat. Commun.Borisova ME, Voigt A, Tollenaere MAX, Sahu SK, Juretschke T, Kreim N, Mailand N, Choudhary C, Bekker-Jensen S, Akutsu M, Wagner SA, Beli PGo to publication →
2018Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligandsNat. Chem. Biol.Gechijian LN, Buckley DL, Lawlor MA, Reyes JM, Paulk J, Ott CJ, Winter GE, Erb MA, Scott TG, Xu M, Seo HS, Dhe-Paganon S, Kwiatkowski NP, Perry JA, Qi J, Gray NS, Bradner JEGo to publication →
2018Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc functionEMBO Rep.Heidelberger JB, Voigt A, Borisova ME, Petrosino G, Ruf S, Wagner SA, Beli PGo to publication →
2018Human tripartite motif protein 52 is required for cell context-dependent proliferationOncotargetBenke S, Agerer B, Haas L, Stöger M, Lercher A, Gabler L, Kiss I, Scinicariello S, Berger W, Bergthaler A, Obenauf AC, Versteeg GAGo to publication →
2018UFD-2 is an adaptor-assisted E3 ligase targeting unfolded proteinsNat. Commun.Hellerschmied D, Roessler M, Lehner A, Gazda L, Stejskal K, Imre R, Mechtler K, Dammermann A, Clausen TGo to publication →
2018Translation Termination Factor GSPT1 Is a Phenotypically Relevant Off-Target of Heterobifunctional Phthalimide DegradersACS Chem. Biol.Ishoey M, Chorn S, Singh N, Jaeger MG, Brand M, Paulk J, Bauer S, Erb MA, Parapatics K, Müller AC, Bennett KL, Ecker GF, Bradner JE, Winter GEGo to publication →
2018p62 filaments capture and present ubiquitinated cargos for autophagyEMBO J.Zaffagnini G, Savova A, Danieli A, Romanov J, Tremel S, Ebner M, Peterbauer T, Sztacho M, Trapannone R, Tarafder AK, Sachse C, Martens SGo to publication →
2018SUMO chain formation relies on the amino-terminal region of SUMO conjugating enzyme and has dedicated substrates in plantsBiochemical J. Tomanov, K., Nehlin, L., Ziba, I., Bachmair, A. Go to publication →
2018Acute Pharmacologic Degradation of a Stable Antigen Enhances Its Direct Presentation on MHC Class I MoleculesFront. Immunol.Moser SC, Voerman JSA, Buckley DL, Winter GE, Schliehe CGo to publication →
2018Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradationNat. Chem. Biol.Olson CM, Jiang B, Erb MA, Liang Y, Doctor ZM, Zhang Z, Zhang T, Kwiatkowski N, Boukhali M, Green JL, Haas W, Nomanbhoy T, Fischer ES, Young RA, Bradner JE, Winter GE, Gray NSGo to publication →
2017Repair of UV-Induced DNA Damage Independent of Nucleotide Excision Repair Is Masked by MUTYHMol. CellMazouzi A, Battistini F, Moser SC, Ferreira da Silva, Wiedner M, Owusu M, Lardeau C-H, Ringler A, Weil B, Neesen J, Orozco M, Kubicek S, Loizou JIGo to publication →
2017Parallel genome-wide screens identify a synthetic viable interaction between the BLM helicase complex and Fanconi anemiaNat. Commun.Moder M, Velimezi G, Owusu M, Mazouzi A, Wiedner M, Ferreira da Silva J, Robinson-Garcia L, Schischlik F, Slavkovsky R, Kralovics R, Schuster M, Bock C, Ideker T, Jackson SP, Menche J, Loizou JIGo to publication →
2017An unfolded protein-induced conformational switch activates mammalian IRE1 eLifeKaragöz GE, Acosta-Alvear D, Nguyen HT, Lee CP, Chu F, Walter PGo to publication →
2017MELK is not necessary for the proliferation of basal-like breast cancer cellseLifeHuang HT, Seo HS, Zhang T, Wang Y, Jiang B, Li Q, Buckley DL, Nabet B, Roberts JM, Paulk J, Dastjerdi S, Winter GE, McLauchlan H, Moran J, Bradner JE, Eck MJ, Dhe-Paganon S, Zhao JJ, Gray NSGo to publication →
2017Long-range allosteric regulation of the human 26S proteasome by 20S proteasome-targeting cancer drugsNat. Commun.Haselbach D , Schrader J, Lambrecht F, Henneberg F, Chari A, Stark HGo to publication →
2017Semisynthetic prion protein (PrP) variants carrying glycan mimics at position 181 and 197 do not form fibrilsChem. Sci.Araman C, Thompson RE, Wang S, Hackl S, Payne RJ, Becker CFWGo to publication →
2017BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 RecruitmentMol. CellWinter GE, Mayer A, Buckley DL, Erb MA, Roderick JE, Vittori S, Reyes JM, di Iulio J, Souza A, Ott CJ, Roberts JM, Zeid R, Scott TG, Paulk J, Lachance K, Olson CM, Dastjerdi S, Bauer S, Lin CY, Gray NS, Kelliher MA, Churchman LS, Bradner JEGo to publication →
2017Transcription control by the ENL YEATS domain in acute leukaemiaNatureErb MA, Scott TG, Li BE, Xie H, Paulk J, Seo HS, Souza A, Roberts JM, Dastjerdi S, Buckley DL, Sanjana NE, Shalem O, Nabet B, Zeid R, Offei-Addo NK, Dhe-Paganon S, Zhang F, Orkin SH, Winter GE, Bradner JEGo to publication →
2016Mechanism of cargo-directed Atg8 conjugation during selective autophagyeLifeFracchiolla D, Sawa-Makarska J, Zens B, Ruiter A, Zaffagnini G, Brezovich A, Romanov J, Runggatscher K, Kraft C, Zagrovic B, Martens SGo to publication →
2016Arginine phosphorylation marks proteins for degradation by a Clp proteaseNatureTrentini DB, Suskiewicz MJ, Heuck A, Kurzbauer R, Deszcz L, Mechtler K, Clausen TGo to publication →
2016Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin LigationMol. CellYamaguchi M, VanderLinden R, Weissmann F, Qiao R, Dube P, Brown NG, Haselbach D, Zhang W, Sidhu SS, Peters JM, Stark H, Schulman BAGo to publication →
2016Structural Basis of Host Autophagy-related Protein 8 (ATG8) Binding by the Irish Potato Famine Pathogen Effector Protein PexRD54J. Biol. Chem.Maqbool A, Hughes RK, Dagdas YF, Tregidgo N, Zess E, Belhaj K, Round A, Bozkurt TO, Kamoun S, Banfield MJGo to publication →
2016Return to quiescence of mouse neural stem cells by degradation of a proactivation proteinScienceUrbán N, van den Berg DL, Forget A, Andersen J, Demmers JA, Hunt C, Ayrault O, Guillemot FGo to publication →
2016Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/CCellBrown NG, VanderLinden R, Watson ER, Weissmann F, Ordureau Am Wu KP, Zhang W, Yu S, Mercedi PY, Harrison JS, Davidson IF, Qiao R, Lu Y, Dube P, Brunner MR, Grace CR, Miller DJ, Haselbach D, Jarvis MA, Yamaguchi M, Yanisheski D, Petzold G, Sidhu SS, Kuhlmann B, Kirschner MW, Harper JW, Peters JM, Stark H, Schulman BAGo to publication →
2016Mechanism of APC/CCDC20 activation by mitotic phosphorylationProc. Natl. Acad. Sci. USAQiao R, Weissmann F, Yamaguchi M, Brown NG, VanderLinden R, Imre R, Jarvis MA, Brunner MR, Davidson IF, Litos G, Haselbach D , Mechtler K, Stark H, Schulman BA, Peters JMGo to publication →
2016An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptoreLifeDagdas YF*, Belhaj K*, Maqbool A, Chaparro-Garcia A, Pandey P, Petre B, Tabassum N, Cruz-Mireles N, Hughes RK, Sklenar J, Win J, Menke F, Findlay K, Banfield MJ, Kamoun S, Bozkurt TOGo to publication →
2015Oligomerization of p62 allows for selection of ubiquitinated cargo and isolation membrane during selective autophagyeLifeWurzer B, Zaffagnini G, Fracchiolla D, Turco E, Abert C, Romanov J, Martens SGo to publication →
2015ProteoPlex: stability optimization of macromolecular complexes by sparse-matrix screening of chemical spaceNat. MethodsChari A*, Haselbach D *, Kirves JM*, Ohmer J, Paknia E, Fischer N, Ganichkin O,Möller V, Frye JJ, Petzold G, Jarvis M, Tietzel M, Grimm C, Peters JM, Schulman BA, Tittmann K, Markl J, Fischer U, Stark H. (*equal contribution)Go to publication →
2015DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradationScienceWinter GE, Buckley DL, Paulk J, Roberts JM, Souza A, Dhe-Paganon S, Bradner JEGo to publication →
2014The eukaryotic N-end rule pathway: conserved mechanisms and diverse functionsTrends in Cell Biol.Gibbs DJ, Bacardit J, Bachmair A, Holdsworth MJGo to publication →
2014Cargo binding to Atg19 unmasks additional Atg8 binding sites to mediate membrane–cargo apposition during selective autophagyNat. Cell Biol.Sawa-Makarska J, Abert C, Romanov J, Zens B, Ibiricu I, Martens SGo to publication →
2014Hsp90-Tau complex reveals molecular basis for specificity in chaperone actionCellKaragöz GE, Duarte AM, Akoury E, Ippel H, Biernat J, Morán Luengo T, Radli M, Didenko T, Nordhues BA, Veprintsev DB, Dickey CA, Mandelkow E, Zweckstetter M, Boelens R, Madl T, Rüdiger SGGo to publication →
2014Nitric oxide sensing in plants is mediated by proteolytic control of group VII ERF transcription factorsMol. CellGibbs DJ, Md Isa N, Movahedi M, Lozano-Juste J, Mendiondo GM, Berckhan S, Marín-de la Rosa N, Vicente Conde J, Sousa Correia C, Pearce SP, Bassel GW, Hamali B, Talloji P, Tomé DF, Coego A, Beynon J, Alabadí D, Bachmair A, León J, Gray JE, Theodoulou FL, Holdsworth MJGo to publication →
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