Publications
Selected Publications
- 2024 Inhibitor-induced supercharging of kinase turnover via endogenous proteolytic circuits bioRxiv Go to publication →
- 2024 Monovalent Pseudo-Natural Product Degraders Supercharge the Native Degradation of IDO1 by KLHDC3 bioRxiv Go to publication →
- 2024 Alkylamine-tethered molecules recruit FBXO22 for targeted protein degradation Nature Communication Go to publication →
- 2024 Orpinolide disrupts a leukemic dependency on cholesterol transport by inhibiting OSBP Nature Chemical Biology Go to publication →
- 2024 Tau fibrils evade autophagy by excessive p62 coating and TAX1BP1 exclusion Science Advances Go to publication →
- 2024 Guardian ubiquitin E3 ligases target cancer-associated APOBEC3 deaminases for degradation to promote human genome integrity bioRxiv Go to publication →
- 2024 A RabGAP negatively regulates plant autophagy and immune trafficking Current Biology Go to publication →
- 2024 Endoplasmic reticulum: Monitoring and maintaining protein and membrane homeostasis in the endoplasmic reticulum by the unfolded protein response Int J Biochem Cell Biol Go to publication →
- 2024 TRIM52 is a primate-specific player in the DNA repair process under tight proteolytic control by a triad of giant E3 ligases bioRxiv Go to publication →
- 2024 Metabolic enzymes moonlight as selective autophagy receptors to protect plants against viral-induced cellular damage bioRxiv Go to publication →
- 2024 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells Science Go to publication →
- 2024 ATG8ylation of vacuolar membrane protects plants against cell wall damage bioRxiv Go to publication →
- 2024 BIG enhances Arg/N-degron pathway-mediated protein degradation to regulate Arabidopsis hypoxia responses and suberin deposition Plant Cell Go to publication →
- 2024 Targeted protein degradation via intramolecular bivalent glues Nature Go to publication →
- 2023 Sequestration of translation initiation factors in p62 condensates Cell Reports Go to publication →
- 2023 Discovery of Molecular Glue Degraders via Isogenic Morphological Profiling ASC Chemical Biology Go to publication →
- 2023 Adult neural stem cells and neurogenesis are resilient to intermittent fasting EMBO Journal Go to publication →
- 2023 IGF2BP1 phosphorylation regulates ribonucleoprotein condensate formation by impairing low-affinity protein and RNA interactions bioRxiv Go to publication →
- 2023 Discovery of a Drug-like, Natural Product-Inspired DCAF11 Ligand Chemotype Nature Communication Go to publication →
- 2023 Optimized infrared photoactivatable ribonucleoside enhanced crosslinking and immunoprecipitation (IR-PAR-CLIP) protocol identifies novel IGF2BP3-interacting RNAs in colon cancer cells. RNA Go to publication →
- 2023 The potential of cross-linking mass spectrometry in the development of protein–protein interaction modulators Current Opinion in Structural Biology Go to publication →
- 2023 SPOP targets the immune transcription factor IRF1 for proteasomal degradation eLife Go to publication →
- 2023 p62 and NBR1 functions are dispensable for aggrephagy in mouse ESCs and ESC-derived neurons Life Science Alliance Go to publication →
- 2023 Lipid saturation controls nuclear envelope function Nature Cell Biology Go to publication →
- 2023 The membrane surface as a platform that organizes cellular and biochemical processes Developmental Cell Go to publication →
- 2023 Analysis of higher plant N-degron pathway components and substrates via expression in S. cerevisiae Methods in Enzymology Go to publication →
- 2023 Protein compactness and interaction valency define the architecture of a biomolecular condensate across scales eLife Go to publication →
- 2023 Cryo-EM structure of the chain-elongating E3 ubiquitin ligase UBR5 EMBO Journal Go to publication →
- 2023 Light-Cleavable Auxiliary for Diselenide–Selenoester Ligations of Peptides and Proteins Chemistry Europe Go to publication →
- 2023 Aggrephagy at a glance Journal of Cell Science Go to publication →
- 2023 Atg8 family proteins, LIR/AIM motifs and other interaction modes Autophagy Reports Go to publication →
- 2023 Stress-induced clustering of the UPR sensor IRE1α is driven by disordered regions within its ER lumenal domain bioRxiv Go to publication →
- 2023 HUWE1 controls tristetraprolin proteasomal degradation by regulating its phosphorylation eLife Go to publication →
- 2023 Structural basis of how the BIRC6/SMAC complex regulates apoptosis and autophagy Science Go to publication →
- 2023 NDP52 acts as a redox sensor in PINK1/Parkin-mediated mitophagy EMBO Journal Go to publication →
- 2023 Shuffled ATG8 interacting motifs form an ancestral bridge between UFMylation and C53-mediated autophagy EMBO Journal Go to publication →
- 2023 Advancing Targeted Protein Degradation via Multiomics Profiling and Artificial Intelligence Journal of American Chemical Society Go to publication →
- 2023 A molecular network of conserved factors keeps ribosomes dormant in the egg Nature Go to publication →
- 2023 E3-Specific Degrader Discovery by Dynamic Tracing of Substrate Receptor Abundance Journal of American Chemical Society Go to publication →
- 2022 Frozen in time: analyzing molecular dynamics with time-resolved cryo-EM Structure Go to publication →
- 2022 Orchestration of selective autophagy by cargo receptors Current Biology Go to publication →
- 2023 SUMO Conjugation and SUMO Chain Formation by Plant Enzymes Methods in Molecular Biology Go to publication →
- 2022 Characterization of ATG8-Family Interactors by Isothermal Titration Calorimetry Methods in Molecular Biology Go to publication →
- 2022 POLθ processes ssDNA gaps and promotes replication fork progression in BRCA1 deficient cells Cell Reports Go to publication →
- 2022 Site-selective photocatalytic functionalization of peptides and proteins at selenocysteine Nature Communications Go to publication →
- 2022 Cryo-EM structure of the chain-elongating E3 ligase UBR5 bioRxiv Go to publication →
- 2022 Functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders Nature Chemical Biology Go to publication →
- 2022 Plant autophagosomes mature into amphisomes prior to their delivery to the central vacuole Journal of Cell Biology Go to publication →
- 2022 Lysosomal enzyme trafficking factor LYSET enables nutritional usage of extracellular proteins Science Go to publication →
- 2022 BacPROTACs mediate targeted protein degradation in bacteria Cell Go to publication →
- 2021 McsB forms a gated kinase chamber to mark aberrant bacterial proteins for degradation eLife Go to publication →
- 2021 E3 ubiquitin ligase RNF213 employs a non-canonical zinc finger active site and is allosterically regulated by ATP bioRxiv Go to publication →
- 2022 Transcriptome, metabolome and suppressor analysis reveal an essential role for the ubiquitin-proteasome system in seedling chloroplast development BMC Plant Biology Go to publication →
- 2022 Autophagy promotes programmed cell death and corpse clearance in specific cell types of the Arabidopsis root cap Current Biology Go to publication →
- 2022 Could a Different View of Quiescence Help Us Understand How Neurogenesis Is Regulated? Frontiers in Neuroscience Go to publication →
- 2022 Expressed Protein Selenoester Ligation Angewandte Chemie International Ed. Go to publication →
- 2022 Cryo-EM structure of the plant 26S proteasome Plant Communications Go to publication →
- 2022 Molecular mechanisms of endomembrane trafficking in plants Plant Cell Go to publication →
- 2022 A yeast-based functional assay to study plant N-degron – N-recognin interactions Frontiers in Plant Science Go to publication →
- 2021 Stem cell quiescence: the challenging path to activation Development Go to publication →
- 2021 AKIRIN2 controls the nuclear import of proteasomes in vertebrates Nature Go to publication →
- 2021 Decomposing the mutational landscape of cancer genomes with RepairSig Cell Systems Go to publication →
- 2021 Wnt/beta-catenin signalling is dispensable for adult neural stem cell homeostasis and activation Development Go to publication →
- 2021 Proteasome and selective autophagy: Brothers-in-arms for organelle quality control Current Opinion in Plant Biology Go to publication →
- 2021 Reconstitution defines the roles of p62, NBR1 and TAX1BP1 in ubiquitin condensate formation and autophagy initiation Nature Communications Go to publication →
- 2021 An oomycete effector subverts host vesicle trafficking to channel starvation-induced autophagy to the pathogen interface eLife Go to publication →
- 2021 The rise of proteome‐wide biophysics Molecular Systems Biology Go to publication →
- 2021 HUWE1 employs a giant substrate-binding ring to feed and regulate its HECT E3 domain Nature Chemical Biology Go to publication →
- 2021 The linear ubiquitin chain assembly complex (LUBAC) generates heterotypic ubiquitin chains eLife Go to publication →
- 2021 Identification and selectivity profiling of small-molecule degraders via multi-omics approaches Cell Chemical Biology Go to publication →
- 2021 Cellular control of protein turnover via modification of the amino terminus International Journal of Molecular Sciences Go to publication →
- 2021 Proteome-wide identification of NEDD8 modification sites reveals distinct proteomes for canonical and atypical NEDDylation Cell Reports Go to publication →
- 2020 EXO70D isoforms mediate selective autophagic degradation of type-A ARR proteins to regulate cytokinin sensitivity Proc. Natl. Acad. Sci. USA Go to publication →
- 2020 Reconstitution of autophagosome nucleation defines Atg9 vesicles as seeds for membrane formation Science Go to publication →
- 2020 A cross-kingdom conserved ER-phagy receptor maintains endoplasmic reticulum homeostasis during stress eLife Go to publication →
- 2020 Rational discovery of molecular glue degraders via scalable chemical profiling Nature Chemical Biology Go to publication →
- 2020 Native Mass Spectrometry Can Effectively Predict PROTAC Efficacy ACS Central Science Go to publication →
- 2020 Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism eLife Go to publication →
- 2020 Quantifying the heterogeneity of macromolecular machines by mass photometry Nature Communications Go to publication →
- 2020 Selective Mediator dependence of cell-type-specifying transcription Nature Genetics Go to publication →
- 2020 A PI3K-WIPI2 positive feedback loop allosterically activates LC3 lipidation in autophagy Journal of Cell Biology Go to publication →
- 2020 Phase separation directs ubiquitination of gene-body nucleosomes Nature Go to publication →
- 2020 Highly Precise Protein Semisynthesis through Ligation–Desulfurization Chemistry in Combination with Phenacyl Protection of Native Cysteines Methods in Molecular Biology Go to publication →
- 2020 Autophagy mediates temporary reprogramming and dedifferentiation in plant somatic cells EMBO Journal Go to publication →
- 2020 Targeted protein degradation: current and future challenges Current Opinion in Chemical Biology Go to publication →
- 2019 Quiescence of Adult Mammalian Neural Stem Cells: A Highly Regulated Rest Neuron Go to publication →
- 2019 The RNA-binding ubiquitin ligase MKRN1 functions in ribosome-associated quality control of poly(A) translation Genome Biolology Go to publication →
- 2019 Id4 promotes the elimination of the pro-activation factor Ascl1 to maintain quiescence of adult hippocampal stem cells eLife Go to publication →
- 2019 Labeling and Natural Post-Translational Modification of Peptides and Proteins via Chemoselective Pd-Catalyzed Prenylation of Cysteine Journal of American Chemical Society Go to publication →
- 2019 Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site Proc. Natl. Acad. Sci. USA Go to publication →
- 2019 N-terminal β-strand underpins biochemical specialization of an ATG8 isoform PLoS Biology Go to publication →
- 2019 Plasticity of the cullin-RING ligase repertoire shapes sensitivity to ligand-induced protein degradation Molecular Cell Go to publication →
- 2019 A repetitive acidic region contributes to the extremely rapid degradation of the cell-context essential protein TRIM52 Scientific Reports Go to publication →
- 2019 MTHFD1 interaction with BRD4 links folate metabolism to transcriptional regulation Nature Genetics Go to publication →
- 2019 FIP200 Claw Domain Binding to p62 Promotes Autophagosome Formation at Ubiquitin Condensates Molecular Cell Go to publication →
- 2019 Structure of McsB, a protein kinase for regulated arginine phosphorylation Nature Chemical Biology Go to publication →
- 2019 Locus-Specific Knock-in of a degradable tag for target validation studies Methods in Molecular Biology Go to publication →
- 2019 Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML Cell Chemical Biology Go to publication →
- 2019 The Scope, Functions, and Dynamics of Posttranslational Protein Modifications Annu. Rev. Plant Biol. Go to publication →
- 2019 Identification and characterization of cancer vulnerabilities via targeted protein degradation Drug Discov. Today Technol. Go to publication →
- 2018 The unfolded protein response and endoplasmic reticulum protein targeting machineries converge on the stress sensor IRE1 eLife Go to publication →
- 2019 Single Posttranslational Modifications in the Central Repeat Domains of Tau4 Impact its Aggregation and Tubulin Binding Angewandte Chemie International Ed. Go to publication →
- 2018 LZTR1 is a regulator of RAS ubiquitination and signaling Science Go to publication →
- 2018 Native chemical ligation in protein synthesis and semi-synthesis Chem. Soc. Rev. Go to publication →
- 2019 Distinct branches of the N-end rule pathway modulate the plant immune response New Phytologist Go to publication →
- 2018 The inner nuclear membrane is a metabolically active territory that generates nuclear lipid droplets Cell Go to publication →
- 2018 Host autophagy machinery is diverted to the pathogen interface to mediate focal defense responses against the Irish potato famine pathogen eLife Go to publication →
- 2018 Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48 Nature Communications Go to publication →
- 2018 Targetable BET proteins- and E2F1-dependent transcriptional program maintains the malignancy of glioblastoma Proc. Natl. Acad. Sci. USA Go to publication →
- 2018 The dTAG system for immediate and target-specific protein degradation Nature Chemical Biology Go to publication →
- 2018 p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage Nature Communications Go to publication →
- 2018 Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands Nature Chemical Biology Go to publication →
- 2018 Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function EMBO Reports Go to publication →
- 2018 Human tripartite motif protein 52 is required for cell context-dependent proliferation Oncotarget Go to publication →
- 2018 UFD-2 is an adaptor-assisted E3 ligase targeting unfolded proteins Nature Communications Go to publication →
- 2018 Translation Termination Factor GSPT1 Is a Phenotypically Relevant Off-Target of Heterobifunctional Phthalimide Degraders ACS Chem. Biol. Go to publication →
- 2018 p62 filaments capture and present ubiquitinated cargos for autophagy EMBO Journal Go to publication →
- 2018 SUMO chain formation relies on the amino-terminal region of SUMO conjugating enzyme and has dedicated substrates in plants Biochemical J. Go to publication →
- 2018 Acute Pharmacologic Degradation of a Stable Antigen Enhances Its Direct Presentation on MHC Class I Molecules Front. Immunol. Go to publication →
- 2018 Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation Nat. Chem. Biol. Go to publication →
- 2017 Repair of UV-Induced DNA Damage Independent of Nucleotide Excision Repair Is Masked by MUTYH Mol. Cell Go to publication →
- 2017 Parallel genome-wide screens identify a synthetic viable interaction between the BLM helicase complex and Fanconi anemia Nat. Commun. Go to publication →
- 2017 An unfolded protein-induced conformational switch activates mammalian IRE1 eLife Go to publication →
- 2017 MELK is not necessary for the proliferation of basal-like breast cancer cells eLife Go to publication →
- 2017 Long-range allosteric regulation of the human 26S proteasome by 20S proteasome-targeting cancer drugs Nat. Commun. Go to publication →
- 2017 Semisynthetic prion protein (PrP) variants carrying glycan mimics at position 181 and 197 do not form fibrils Chem. Sci. Go to publication →
- 2017 BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment Mol. Cell Go to publication →
- 2017 Transcription control by the ENL YEATS domain in acute leukaemia Nature Go to publication →
- 2016 Mechanism of cargo-directed Atg8 conjugation during selective autophagy eLife Go to publication →
- 2016 Arginine phosphorylation marks proteins for degradation by a Clp protease Nature Go to publication →
- 2016 Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation Mol. Cell Go to publication →
- 2016 Structural Basis of Host Autophagy-related Protein 8 (ATG8) Binding by the Irish Potato Famine Pathogen Effector Protein PexRD54 J. Biol. Chem. Go to publication →
- 2016 Return to quiescence of mouse neural stem cells by degradation of a proactivation protein Science Go to publication →
- 2016 Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C Cell Go to publication →
- 2016 Mechanism of APC/CCDC20 activation by mitotic phosphorylation Proc. Natl. Acad. Sci. USA Go to publication →
- 2016 An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptor eLife Go to publication →
- 2015 Oligomerization of p62 allows for selection of ubiquitinated cargo and isolation membrane during selective autophagy eLife Go to publication →
- 2015 ProteoPlex: stability optimization of macromolecular complexes by sparse-matrix screening of chemical space Nat. Methods Go to publication →
- 2015 DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation Science Go to publication →
- 2014 The eukaryotic N-end rule pathway: conserved mechanisms and diverse functions Trends in Cell Biol. Go to publication →
- 2014 Cargo binding to Atg19 unmasks additional Atg8 binding sites to mediate membrane–cargo apposition during selective autophagy Nat. Cell Biol. Go to publication →
- 2014 Hsp90-Tau complex reveals molecular basis for specificity in chaperone action Cell Go to publication →
- 2014 Nitric oxide sensing in plants is mediated by proteolytic control of group VII ERF transcription factors Mol. Cell Go to publication →