From small molecules to complex organelles

Latest News

  • November 18, 2022 Blocking DNA production in cancer therapy by targeting POLΘ In a recent study, researchers from Joanna Loizou’s group from CeMM and the Medical University of Vienna investigated the POLΘ enzyme and the role it plays in DNA repair. Inhibiting POLΘ represents a new approach for developing specific therapies, in particular for patients with BRCA1 mutations. The study has been published in Cell Reports. Read more →
  • November 7, 2022 Preventing resistance in cancer therapy The latest developmental drugs, particularly for the use in oncology, rely on the targeted degradation of harmful pathogenic proteins. In a recent study, researchers in the lab of Georg Winter at CeMM and their collaborators identify potential resistance mechanisms and provide insights on how to overcome them. Their study has been published in Nature Chemical Biology. Read more →
  • October 21, 2022 Plant autophagosomes mature into amphisomes prior to their delivery to the central vacuole Researchers in the lab of Yasin Dagdas at the GMI and their collaborators reveal a “hub and spoke” distribution model used by plant cells to regulate autophagic flux and thus efficiently coordinate cellular recycling. Their work has been published in the Journal of Cell Biology. Read more →

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About the Program

Targeted Protein Degradation: From small molecules to complex organelles

Our Special Research Program is a collaborative research platform to unravel how proteins are targeted for degradation. We focus on the two major cellular proteolytic pathways, the ubiquitin-proteasome system (UPS) and autophagy, and the crosstalk between them in the cytoplasm and in the nucleus. Furthermore, we investigate how small molecules can be used to chemically reprogram the degradation systems, enabling the targeted proteolysis of selected proteins in a spatially and temporally controlled manner …

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Selected Publications

  • 2021 HUWE1 employs a giant substrate-binding ring to feed and regulate its HECT E3 domain Nat. Chem. Biol. Grabarczyk DB, Petrova OA, Deszcz L, Kurzbauer R, Murphy P, Ahel J, Vogel A, Gogova R, Faas V, Kordic D, Schleiffer A, Meinhart A, Imre R, Lehner A, Neuhold J, Bader G, Stolt-Bergner P, Böttcher J, Wolkerstorfer B, Fischer G, Grishkovskaya I, Haselbach D, Kessler D, Clausen T Go to publication →
  • 2020 Reconstitution of autophagosome nucleation defines Atg9 vesicles as seeds for membrane formation Science Sawa-Makarska J, Baumann V, Coudevylle N, von Bülow S, Nogellova V, Abert C, Schuschnig M, Graef M, Hummer G, Martens S Go to publication →
  • 2020 A cross-kingdom conserved ER-phagy receptor maintains endoplasmic reticulum homeostasis during stress eLife Stephani M, Picchianti L, Gajic A, Beveridge R, Skarwan R, Sanchez de Medina Hernandez V, Mohseni A, Clavel M, Zeng Y, Naumann C, Matuszkiewicz M, Turco E, Loefke C, Li B, Durnberger G, Schutzbier M, Chen HT, Abdrakhmanov A, Savova A, Chia KS, Djamei A, Schaffner I, Abel S, Jiang L, Mechtler K, Ikeda F, Martens S, Clausen T, Dagdas Y Go to publication →