From small molecules to complex organelles

Latest News

  • June 23, 2022 BacPROTACs mediate targeted protein degradation in bacteria Scientists in the lab of Tim Clausen at the IMP and their international collaborators present an innovative and broadly applicable strategy pointing to an entirely new type of antibiotics: bacterial proteolysis targeting chimeras, or BacPROTACs. Their study has been published in the journal Cell. Read more →
  • May 4, 2022 The ÖAW elected Alwin Köhler as corresponding member and Georg Winter into its Young Academy Two members of our Special Research Program, Alwin Köhler (Max Perutz Labs) and Georg Winter (CeMM), have been elected as members to the Austrian Academy of Sciences (ÖAW): Alwin Köhler as a corresponding member, and Georg Winter as new member to the Young Academy. Read more →
  • March 18, 2022 ERC Consolidator Grant awarded to Yasin Dagdas The European Research Council (ERC) has awarded a Consolidator Grant to Yasin Dagdas, group leader at the GMI and member of our Special Research Program, to investigate the role of autophagy in the rescue of stalled ribosome. Read more →

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About the Program

Targeted Protein Degradation: From small molecules to complex organelles

Our Special Research Program is a collaborative research platform to unravel how proteins are targeted for degradation. We focus on the two major cellular proteolytic pathways, the ubiquitin-proteasome system (UPS) and autophagy, and the crosstalk between them in the cytoplasm and in the nucleus. Furthermore, we investigate how small molecules can be used to chemically reprogram the degradation systems, enabling the targeted proteolysis of selected proteins in a spatially and temporally controlled manner …

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Selected Publications

  • 2021 HUWE1 employs a giant substrate-binding ring to feed and regulate its HECT E3 domain Nature Chemical Biology Grabarczyk DB, Petrova OA, Deszcz L, Kurzbauer R, Murphy P, Ahel J, Vogel A, Gogova R, Faas V, Kordic D, Schleiffer A, Meinhart A, Imre R, Lehner A, Neuhold J, Bader G, Stolt-Bergner P, Böttcher J, Wolkerstorfer B, Fischer G, Grishkovskaya I, Haselbach D, Kessler D, Clausen T Go to publication →
  • 2020 Reconstitution of autophagosome nucleation defines Atg9 vesicles as seeds for membrane formation Science Sawa-Makarska J, Baumann V, Coudevylle N, von Bülow S, Nogellova V, Abert C, Schuschnig M, Graef M, Hummer G, Martens S Go to publication →
  • 2020 A cross-kingdom conserved ER-phagy receptor maintains endoplasmic reticulum homeostasis during stress eLife Stephani M, Picchianti L, Gajic A, Beveridge R, Skarwan R, Sanchez de Medina Hernandez V, Mohseni A, Clavel M, Zeng Y, Naumann C, Matuszkiewicz M, Turco E, Loefke C, Li B, Durnberger G, Schutzbier M, Chen HT, Abdrakhmanov A, Savova A, Chia KS, Djamei A, Schaffner I, Abel S, Jiang L, Mechtler K, Ikeda F, Martens S, Clausen T, Dagdas Y Go to publication →