From small molecules to complex organelles

Latest News

April 11, 2024 ERC Advanced Grant for Tim Clausen to study protein folding in muscle Tim Clausen, IMP Senior Group Leader and member of our Special Research Program, has been awarded an Advanced Grant from the European Research Council (ERC) to investigate how protein misfolding leads to disease by focusing on hypertrophic cardiomyopathies (HCM), a common inherited cardiac condition characterised by thickened heart walls and early death. Read more →
March 4, 2024 Open PhD positions in labs of our Special Research Program Seven group leaders within the Special Resesarch Program (SFB) in Targeted Protein Degradation are recruiting PhD students as part of the Vienna BioCenter PhD Program, which has now opened the Spring Call 2024. Read more →
February 22, 2024 New System Triggers Cellular Waste Disposal Research teams led by Georg Winter (CeMM Group Leader and member of our SFB) and Alessio Ciulli (University of Dundee) have found a new system that triggers cellular waste disposal. Published in the journal Nature, their groundbreaking findings shed light on the mechanisms and the therapeutic opportunities of this system. Read more →

About the Program

Targeted Protein Degradation: From small molecules to complex organelles

Our Special Research Program is a collaborative research platform to unravel how proteins are targeted for degradation. We focus on the two major cellular proteolytic pathways, the ubiquitin-proteasome system (UPS) and autophagy, and the crosstalk between them in the cytoplasm and in the nucleus. Furthermore, we investigate how small molecules can be used to chemically reprogram the degradation systems, enabling the targeted proteolysis of selected proteins in a spatially and temporally controlled manner …

Selected Publications

2024 Targeted protein degradation via intramolecular bivalent glues Nature Hsia O*, Hinterndorfer M*, Cowan AD*, Iso K, Ishida T, Sundaramoorthy R, Nakasone MA, Imrichova H, Schätz C, Rukavina A, Husnjak K, Wegner M, Correa-Sáez A, Craigon C, Casement R, Maniaci C, Testa A, Kaulich M, Dikic I, Winter GE†, Ciulli A† Go to publication →
2023 Structural basis of how the BIRC6/SMAC complex regulates apoptosis and autophagy Science Ehrmann JF, Grabarczyk DB, Heinke M, Deszcz L, Kurzbauer R, Hudecz O, Shulkina A, Gogova R, Meinhart A, Versteeg GA, Clausen T Go to publication →
2023 Shuffled ATG8 interacting motifs form an ancestral bridge between UFMylation and C53-mediated autophagy EMBO Journal Picchianti L, Sánchez de Medina Hernández V, Zhan N, Irwin NAT, Stephani M, Hornegger H, Beveridge R, Sawa-Makarska J, Lendl T, Grujic N, Martens S, Richards TA, Clausen T, Ramundo S, Karagöz E, Dagdas Y Go to publication →

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