From small molecules to complex organelles

Latest News

  • April 13, 2024 Postdoc Position in Re-programming Autophagy in the Martens lab in collaboration with the Winter lab A postdoc position is available in the lab of Sascha Martens at the Max Perutz Labs, Vienna BioCenter, in collaboration with the lab of Georg Winter at CeMM. Read more →
  • April 11, 2024 ERC Advanced Grant for Tim Clausen to study protein folding in muscle Tim Clausen, IMP Senior Group Leader and member of our Special Research Program, has been awarded an Advanced Grant from the European Research Council (ERC) to investigate how protein misfolding leads to disease by focusing on hypertrophic cardiomyopathies (HCM), a common inherited cardiac condition characterised by thickened heart walls and early death. Read more →
  • April 2, 2024 Master’s Thesis in cryo electron microscopy There is an opportunity for a Master’s thesis in the lab of David Haselbach in the Research Institute of Molecular Pathology (IMP). The lab is studying the dynamics of macromolecular machines using single particle cryo EM. Read more →

Show all News

About the Program

Targeted Protein Degradation: From small molecules to complex organelles

Our Special Research Program is a collaborative research platform to unravel how proteins are targeted for degradation. We focus on the two major cellular proteolytic pathways, the ubiquitin-proteasome system (UPS) and autophagy, and the crosstalk between them in the cytoplasm and in the nucleus. Furthermore, we investigate how small molecules can be used to chemically reprogram the degradation systems, enabling the targeted proteolysis of selected proteins in a spatially and temporally controlled manner …

Read more

Selected Publications

  • 2024 Targeted protein degradation via intramolecular bivalent glues Nature Hsia O*, Hinterndorfer M*, Cowan AD*, Iso K, Ishida T, Sundaramoorthy R, Nakasone MA, Imrichova H, Schätz C, Rukavina A, Husnjak K, Wegner M, Correa-Sáez A, Craigon C, Casement R, Maniaci C, Testa A, Kaulich M, Dikic I, Winter GE†, Ciulli A† Go to publication →
  • 2023 Structural basis of how the BIRC6/SMAC complex regulates apoptosis and autophagy Science Ehrmann JF, Grabarczyk DB, Heinke M, Deszcz L, Kurzbauer R, Hudecz O, Shulkina A, Gogova R, Meinhart A, Versteeg GA, Clausen T Go to publication →
  • 2023 Shuffled ATG8 interacting motifs form an ancestral bridge between UFMylation and C53-mediated autophagy EMBO Journal Picchianti L, Sánchez de Medina Hernández V, Zhan N, Irwin NAT, Stephani M, Hornegger H, Beveridge R, Sawa-Makarska J, Lendl T, Grujic N, Martens S, Richards TA, Clausen T, Ramundo S, Karagöz E, Dagdas Y Go to publication →